Publication Name	World Journal of Gastroenterology
Manuscript ID	117611
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Leucine-rich α-2-glycoprotein in Taiwanese inflammatory bowel disease: Strengths and limitations of a novel serum marker
Manuscript Source	Invited Manuscript
All Author List	Rupa Guha and Aditi Banerjee
Funding Agency and Grant Number
Corresponding Author	Aditi Banerjee, Associate Professor, Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, United States. aditi.banerjee@som.umaryland.edu
Key Words	Leucine-rich α2 glycoprotein; Inflammatory bowel disease; Ulcerative colitis; Crohn’s disease; Endoscopic activity; Serum biomarker; Fecal calprotectin
Core Tip	Leucine-rich α-2-glycoprotein (LRG) is an emerging serum biomarker that showed modest but incremental value for predicting endoscopic activity in Taiwanese patients with ulcerative colitis and Crohn’s disease, particularly when combined with C-reactive protein, hemoglobin, and albumin. This Letter highlights methodological issues and clinical implications of LRG testing, including its lower accuracy than fecal calprotectin, single-center data, and lack of standardized cutoffs, and argues that future multicenter, multi-ethnic studies should position LRG within composite biomarker panels and stepwise algorithms for noninvasive assessment of inflammatory bowel disease activity.
Citation	Guha R, Banerjee A. Leucine-rich α-2-glycoprotein in Taiwanese inflammatory bowel disease: Strengths and limitations of a novel serum marker. World J Gastroenterol 2026; In press

Received	2025-12-11 01:25
Peer-Review Started	2025-12-11 01:25
First Decision by Editorial Office Director	2026-01-23 09:24
Return for Revision	2026-01-23 09:24
Revised	2026-02-02 03:48
Publication Fee Transferred
Second Decision by Editor	2026-03-03 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-03 07:08
Articles in Press	2026-03-03 07:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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