Publication Name	World Journal of Stem Cells
Manuscript ID	117689
Country	India

Category	Orthopedics
Manuscript Type	Review
Article Title	Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications
Manuscript Source	Invited Manuscript
All Author List	Ashwini Raja, Naveen Jeyaraman, Ashika Mudilikulam Sukumaran, Aadithya Siddarth Sridhar, Swaminathan Ramasubramanian, Arulkumar Nallakumarasamy, Sathish Muthu and Madhan Jeyaraman
Funding Agency and Grant Number
Corresponding Author	Madhan Jeyaraman, MD, PhD, Researcher, Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Velappanchavadi, Chennai 600077, Tamil Nadu, India. madhanjeyaraman@gmail.com
Key Words	Knee osteoarthritis; Bone marrow; Mesenchymal stromal cells; Extracellular vesicles; Exosomes; Hydrogels
Core Tip	Bone marrow mesenchymal stromal cell exosomes show promise as cell-free therapeutics for knee osteoarthritis by delivering microRNAs and long noncoding RNAs that modulate nuclear factor kappa B, Wnt/β-catenin, phosphatidylinositol 3-kinase/protein kinase B/mechanistic target of rapamycin and mitogen-activated protein kinases pathways. They suppress chondrocyte apoptosis, enhance matrix synthesis, polarise macrophages, and reduce pain behaviours. Delivery innovations like hydrogels improve retention, but rigorous Minimal Information for Studies of Extracellular Vesicles 2023-compliant characterisation and adequately powered randomised trials remain essential before clinical translation as disease-modifying therapy.
Citation	Raja A, Jeyaraman N, Sukumaran AM, Sridhar AS, Ramasubramanian S, Nallakumarasamy A, Muthu S, Jeyaraman M. Bone marrow mesenchymal stromal cell-derived exosomes in knee osteoarthritis: Bridging mechanistic understanding to clinical applications. World J Stem Cells 2026; In press

Received	2025-12-15 01:38
Peer-Review Started	2025-12-15 01:38
First Decision by Editorial Office Director	2026-01-16 03:40
Return for Revision	2026-01-16 03:40
Revised	2026-01-27 19:09
Publication Fee Transferred
Second Decision by Editor	2026-03-02 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-03 07:22
Articles in Press	2026-03-03 07:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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