Publication Name	World Journal of Stem Cells
Manuscript ID	117707
Country	South Korea

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice
Manuscript Source	Invited Manuscript
All Author List	Khan-Erdene Tsolmon, Zolzaya Bavuu, Solar Sora Kim, Heon-Sang Jeong, Dongsun Park and Yun-Bae Kim
Funding Agency and Grant Number	Funding Agency Grant Number Regional Innovation System & Education Global University 30 Program Through the Chungbuk Regional Innovation System & Education Center 2025-RISE-11-014
Corresponding Author	Yun-Bae Kim, PhD, Professor, College of Veterinary Medicine, Chungbuk National University, 1 Chungdaero (Gaesin-dong), Cheongju 28644, Chungbuk, South Korea. solar93@cbu.ac.kr
Key Words	Aging; Physical activity; Cognitive function; Amniotic membrane stem cell; Extracellular vesicle; Growth factor; Neurotrophic factor
Core Tip	We obtained a large amount of extracellular vesicles containing high concentrations of growth factors and neurotrophic factors via hypoxic cultivation of amniotic membrane stem cells. The extracellular vesicles ameliorated physical and cognitive dysfunctions by recovering anti-aging factors and energy sources, in the brain and muscles, such as brain-derived neurotrophic factor, sirtuin 1, glycogen, acetylcholine, and antioxidation.
Citation	Tsolmon KE, Bavuu Z, Kim SS, Jeong HS, Park D, Kim YB. Hypoxia-conditioned extracellular vesicles from human amniotic membrane stem cells attenuate D-galactose-induced aging in mice. World J Stem Cells 2026; In press

Received	2025-12-15 03:48
Peer-Review Started	2025-12-15 03:48
First Decision by Editorial Office Director	2026-01-09 07:58
Return for Revision	2026-01-09 07:58
Revised	2026-01-17 10:17
Publication Fee Transferred	2026-01-19 01:59
Second Decision by Editor	2026-03-02 02:51
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 09:09
Articles in Press	2026-03-09 09:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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