Publication Name	World Journal of Critical Care Medicine
Manuscript ID	117717
Country	Pakistan

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Effects of ketone bodies supplementation in patients with heart failure: A systematic review and meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Ahmed K Siddiqi, Syed S Javaid, Akash Kumar, Nomesh Kumar, Mateen Ahmad, Shanzay Akhtar, Ahsan R Raja, Diksha Ladhani, Nisha Kumari and Sooraj Kumar
Funding Agency and Grant Number
Corresponding Author	Akash Kumar, Doctorate Student, Researcher, Medical Research Center, Liaquat University of Medical and Health Sciences, Indus Highway, Jamshoro 76080, Sindh, Pakistan. akashdeewan4@gmail.com
Key Words	Ketone bodies; Heart failure; Cardiac output; Left ventricular ejection fraction; 3-β-hydroxybutyrate
Core Tip	Metabolic modulation has emerged as a novel therapeutic strategy in heart failure (HF). This systematic review and meta-analysis of randomized controlled trials demonstrates that ketone body supplementation, particularly β-hydroxybutyrate, significantly improves cardiac output, left ventricular ejection fraction, and key hemodynamic parameters while reducing systemic vascular resistance and pulmonary capillary wedge pressure in patients with HF. These findings highlight the potential role of ketone bodies as an adjunctive metabolic therapy to enhance myocardial efficiency and hemodynamic performance, especially in heart failure with reduced ejection fraction.
Citation	Siddiqi AK, Javaid SS, Kumar A, Kumar N, Ahmad M, Akhtar S, Raja AR, Ladhani D, Kumar S, Kumari N. Effects of ketone bodies supplementation in patients with heart failure: A systematic review and meta-analysis. World J Crit Care Med 2026; In press

Received	2025-12-15 03:16
Peer-Review Started	2025-12-15 03:17
First Decision by Editorial Office Director	2025-12-31 08:21
Return for Revision	2025-12-31 08:21
Revised	2026-01-12 18:11
Publication Fee Transferred
Second Decision by Editor	2026-04-13 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-13 03:34
Articles in Press	2026-04-13 03:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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