Publication Name	World Journal of Gastroenterology
Manuscript ID	117813
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Advancing the clinical translation of triptolide and quercetin in hepatocellular carcinoma: A commentary on dual JAK-STAT/mTOR inhibition
Manuscript Source	Invited Manuscript
All Author List	Hua Liu, Wei-Yi Jiang and Fei-Fei Mao
Funding Agency and Grant Number
Corresponding Author	Fei-Fei Mao, Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, No. 227 Chongqing South Road, Shanghai 200086, China. maofeifei01@126.com
Key Words	Hepatocellular carcinoma; Combination chemotherapy; Triptolide; Quercetin; Janus kinase-signal transducer and activator of transcription pathway; Mammalian target of rapamycin pathway
Core Tip	Tong et al provide a robust preclinical foundation for the combined triptolide and quercetin therapy for hepatocellular carcinoma. They demonstrate synergistic anti-tumor activity through a multi-pathway mechanism where both compounds bind to key proteins like Janus kinase 1, signal transducer and activator of transcription 3, phosphoinositide 3-kinases, and mammalian target of rapamycin, disrupting carcinogenic signaling. This research adds to the growing body of work on natural product-based cancer therapies. To advance this promising start, future investigations using immunocompetent models, detailed pharmacokinetic studies, and deeper mechanistic validation are essential. Such efforts may translate these findings into a viable clinical strategy, aligning with the broader push toward precision medicine in oncology.
Citation	Liu H, Jiang WY, Mao FF. Advancing the clinical translation of triptolide and quercetin in hepatocellular carcinoma: A commentary on dual JAK-STAT/mTOR inhibition. World J Gastroenterol 2026; In press

Received	2025-12-18 10:48
Peer-Review Started	2025-12-18 10:48
First Decision by Editorial Office Director	2026-01-15 07:38
Return for Revision	2026-01-15 07:38
Revised	2026-01-21 13:50
Publication Fee Transferred
Second Decision by Editor	2026-03-06 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 08:20
Articles in Press	2026-03-06 08:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com