Publication Name	World Journal of Cardiology
Manuscript ID	117884
Country	Greece

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Transcatheter aortic valve implantation beyond 85 years: Age is no longer the limiting factor, but risk stratification still matters
Manuscript Source	Invited Manuscript
All Author List	Nikolaos Ktenopoulos, Nikias Milaras, Anastasios Apostolos, Constantinos Tsioufis, Konstantinos Toutouzas and Skevos Sideris
Funding Agency and Grant Number
Corresponding Author	Nikias Milaras, MD, First Department of Cardiology, National and Kapodistrian University of Athens, Hippokration General Hospital of Athens, Vasilissis Sofias 114, Athens 11527, Greece. nikiasmilaras@gmail.com
Key Words	Transcatheter aortic valve implantation; Aortic stenosis; Elderly patients; Transcatheter aortic valve implantation; Risk stratification; Frailty; Survival outcomes
Core Tip	As transcatheter aortic valve implantation expands into younger populations, chronological age alone is no longer an appropriate barrier to intervention. The study by Algethami et al demonstrates favorable mid-term survival in patients aged 85 years and older, reinforcing the safety and feasibility of transcatheter aortic valve implantation in carefully selected individuals. Importantly, the identification of obesity as a predictor of early mortality highlights the limitations of age-based risk scores and underscores the need for biology- and comorbidity-driven patient selection within multidisciplinary heart teams.
Citation	Ktenopoulos N, Milaras N, Apostolos A, Tsioufis C, Toutouzas K, Sideris S. Letter to the Editor: Transcatheter aortic valve implantation beyond 85 years: Age is no longer the limiting factor, but risk stratification still matters. World J Cardiol 2026; In press

Received	2025-12-18 01:16
Peer-Review Started	2025-12-18 01:16
First Decision by Editorial Office Director	2026-01-08 07:34
Return for Revision	2026-01-08 07:34
Revised	2026-01-19 15:56
Publication Fee Transferred
Second Decision by Editor	2026-05-12 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-12 08:26
Articles in Press	2026-05-12 08:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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