Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117886
Country	China

Category	Pathology
Manuscript Type	Case Report
Article Title	Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Xue Wen, Jie-Ying Qiu, Jun Li, Zheng-Rong Mao and Wei-Qiang Wu
Funding Agency and Grant Number
Corresponding Author	Wei-Qiang Wu, Professor, Department of Pathology, First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. wuweiqiang@zju.edu.cn
Key Words	Duodenal tumor; Pyloric gland-type adenoma; Signet-ring cell carcinoma; Immunohistochemistry; Next-generation sequencing; Case report
Core Tip	We report the first documented case of duodenal signet-ring cell carcinoma arising from a pyloric gland adenoma, characterized by distinctive molecular findings identified through next-generation sequencing. Our data highlight variants in RN7SL1 and MUC6, as well as altered expression of the somatic mitochondrial genes MT-CO2, MT-CO1, MT-ND1, MT-ND4 and MT-CO3, suggesting a novel pathogenic mechanism. This case underscores the value of next-generation sequencing in diagnosing rare gastrointestinal neoplasms and broadens our understanding of signet-ring cell carcinoma development.
Citation	Wen X, Qiu JY, Li J, Mao ZR, Wu WQ. Duodenal signet-ring carcinoma arising in pyloric gland adenoma with RN7SL1/MUC6 upregulation and mitochondrial dysregulation: A case report. World J Gastrointest Oncol 2026; In press

Received	2025-12-18 10:59
Peer-Review Started	2025-12-18 11:00
First Decision by Editorial Office Director	2026-01-14 02:53
Return for Revision	2026-01-14 02:53
Revised	2026-02-04 01:51
Publication Fee Transferred	2026-02-11 01:05
Second Decision by Editor	2026-04-03 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 06:12
Articles in Press	2026-04-03 06:12
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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