Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	117912
Country	China

Category	Oncology
Manuscript Type	Randomized Controlled Trial
Article Title	Investigation of interaction between sodium-glucose cotransporter 2 inhibitors and FOLFOX with colorectal cancer and type 2 diabetes
Manuscript Source	Unsolicited Manuscript
All Author List	Bin Liu, Ning Su, Qing-Shi Lin, Yan-Qin Huang and Shao-Feng Chen
Funding Agency and Grant Number
Corresponding Author	Shao-Feng Chen, Associate Chief Pharmacist, Department of Pharmacy, Zhongshan Hospital of Xiamen University, School of Medicine, Xiamen University, No. 201 Hubin South Road, Xiamen 361004, Fujian Province, China. csfcby@163.com
Key Words	Sodium-glucose cotransporter 2 inhibitors; Colorectal cancer; mFOLFOX6; Type 2 diabetes mellitus; Survival rate; Dapagliflozin
Core Tip	In this study, we evaluated the addition of the sodium-glucose cotransporter 2 inhibitor dapagliflozin to standard mFOLFOX6 chemotherapy in patients with stage III colorectal cancer and type 2 diabetes mellitus after curative resection. The combination significantly improved glycemic control, reduced carcinoembryonic antigen levels, and enhanced 3-year disease-free survival without increasing severe chemotherapy-related toxicity. These findings suggest that sodium-glucose cotransporter 2 inhibitor may offer dual metabolic and oncological benefits in this high-risk comorbid population, supporting its repurposing as an adjunct to adjuvant chemotherapy.
Citation	Liu B, Su N, Lin QS, Huang YQ, Chen SF. Investigation of interaction between sodium-glucose cotransporter 2 inhibitors and FOLFOX with colorectal cancer and type 2 diabetes. World J Gastrointest Oncol 2026; In press

Received	2026-01-16 09:40
Peer-Review Started	2026-01-16 09:40
First Decision by Editorial Office Director	2026-01-27 07:27
Return for Revision	2026-01-27 07:27
Revised	2026-02-02 07:41
Publication Fee Transferred	2026-02-05 09:07
Second Decision by Editor	2026-03-06 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 07:29
Articles in Press	2026-03-06 07:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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