| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Basic Study |
| Article Title |
Daming capsule combined with SGLT2i confers protection against diabetes with myocardial ischemia/reperfusion injury induced ferroptosis via AMPK
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xian Yang, Yong-Ting Zhao, Han Liu, Ru-Xin Wang, Liang-Yan Wu, Hao-Wen Ye, Yun Wen, Jia-Xin Wang, Mei-Xin Yu, Cai-Xia Ma, Xiao-Fang Zhang and Li-Hong Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Talent Introduction Funding Project of the First Affiliated Hospital of Jinan University |
808026 |
| Guangdong Medical Science and Technology Research Foundation |
B2023119 |
| Administration of Traditional Chinese Medicine of Guangdong Province, China |
20251082 |
| Guangdong Basic and Applied Basic Research Foundation |
2023A1515110934 |
|
| Corresponding Author |
Li-Hong Wang, Department of Endocrinology and Metabolism, First Affiliated Hospital of Jinan University, Guangzhou, China, Department of Endocrinology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. Electronic address: nd6688@163.com., Guangzhou 510630, Guangdong Province, China. lihongwang1688@jnu.edu.cn |
| Key Words |
Diabetes mellitus; Myocardial ischemia/reperfusion; Ferroptosis; Sodium-dependent glucose transporters 2 inhibitor; Daming capsule |
| Core Tip |
This study demonstrated the important role of ferroptosis in diabetes mellitus (DM) with myocardial ischemia-reperfusion (I/R) injury. For the first time, we advocated for an integrated Chinese and Western medicine approach to treating DM with I/R. Daming capsule and sodium-dependent glucose transporters 2 inhibitor reduced lipid peroxidation and iron deposition synergistically via adenosine monophosphate-activated protein kinase, thereby inhibiting ferroptosis and improving cardiac function. |
| Citation |
Yang X, Zhao YT, Liu H, Wang RX, Wu LY, Ye HW, Wen Y, Wang JX, Yu MX, Ma CX, Zhang XF, Wang LH. Daming capsule combined with SGLT2i confers protection against diabetes with myocardial ischemia/reperfusion injury induced ferroptosis via AMPK. World J Cardiol 2026; In press |
