Publication Name	World Journal of Radiology
Manuscript ID	117936
Country	India

Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Prospective Study
Article Title	Radiologic progression with minimal functional decline in cystic fibrosis: Insights from a prospective study
Manuscript Source	Invited Manuscript
All Author List	Jan Mohd Suhail, Mohmed Imran Wagay, Arshed Hussain Parry, Irshad Mohiuddin Bhat, Riaz Rasool Sheikh and Mushtaq Ahmad Bhat
Funding Agency and Grant Number
Corresponding Author	Arshed Hussain Parry, Assistant Professor, Department of Radiodiagnosis and Imaging, Government Medical College, 10, Karanagar, Srinagar 190010, Jammu and Kashmir, India. arshedparry@gmail.com
Key Words	Cystic fibrosis; High-resolution computed tomography chest; Pulmonary function test; Bhalla scoring system; Bronchiectasis
Core Tip	This study conducted a longitudinal follow-up of pediatric patients with cystic fibrosis (CF) using a combination of high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs). The findings demonstrated that HRCT was superior to PFTs in identifying worsening lung disease. HRCT based Bhalla scores showed a marked increase, with an approximately 50% worsening after one year of follow-up compared to baseline. In contrast, pulmonary function indices, including forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and the FEV₁/FVC ratio, demonstrated only minimal and statistically non-significant declines ranging from 2.9% to 5.2%. These results underscore that HRCT is a more sensitive modality than PFT for assessing disease progression in CF.
Citation	Suhail JM, Wagay MI, Parry AH, Bhat IM, Sheikh RR, Bhat MA. Radiologic progression with minimal functional decline in cystic fibrosis: Insights from a prospective study. World J Radiol 2026; In press

Received	2025-12-18 15:50
Peer-Review Started	2025-12-18 15:50
First Decision by Editorial Office Director	2026-02-13 07:32
Return for Revision	2026-02-13 07:32
Revised	2026-02-19 07:17
Publication Fee Transferred
Second Decision by Editor	2026-03-13 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 08:34
Articles in Press	2026-03-13 08:34
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8470 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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