Publication Name	World Journal of Gastroenterology
Manuscript ID	117959
Country	Sweden

Category	Gastroenterology & Hepatology
Manuscript Type	Clinical Trials Study
Article Title	Effects of Lactiplantibacillus plantarum 299v and Lactiplantibacillus plantarum GOS42 on gastrointestinal symptoms in healthy adults with occasional constipation
Manuscript Source	Unsolicited Manuscript
All Author List	Gunilla Önning, Christina Skovgaard Vegge, Caroline Montelius, Erin Diane Lewis, Huda Al-Wahsh, Marc Moulin, David Cecil Crowley and Najla Guthrie
Funding Agency and Grant Number
Corresponding Author	Gunilla Önning, Adjunct Professor, Research and Development, Probi AB, Ideongatan 1A, Lund 22370, Sweden. gunilla.onning@probi.com
Key Words	Occasional constipation; Stool frequency; Gut transit time; Bristol Stool Scale; Flatulence; Probiotics
Core Tip	The strain Lactiplantibacillus plantarum (L. plantarum) 299v (Lp299v) has previously been shown to have positive effects on irritable bowel syndrome. For the first time, a randomized, double-blind, placebo-controlled study has evaluated the effects of Lp299v, together with a small amount of a secondary strain (L. plantarum GOS42), on constipation in otherwise healthy subjects. Supplementation of these two probiotic strains for eight weeks had a significant positive effect compared to placebo on various constipation-related symptoms such as number of weekly bowel movements (BMs), stool consistency, percentage of stools with hard/lumpy consistency, flatulence, and satisfaction with BM regularity.
Citation	Önning G, Vegge CS, Montelius C, Lewis ED, Al-Wahsh H, Moulin M, Crowley DC, Guthrie N. Effects of Lactiplantibacillus plantarum 299v and Lactiplantibacillus plantarum GOS42 on gastrointestinal symptoms in healthy adults with occasional constipation. World J Gastroenterol 2026; In press

Received	2025-12-22 07:08
Peer-Review Started	2025-12-22 07:08
First Decision by Editorial Office Director	2026-01-16 07:26
Return for Revision	2026-01-16 07:26
Revised	2026-01-28 12:20
Publication Fee Transferred	2026-02-05 09:47
Second Decision by Editor	2026-02-28 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-28 06:21
Articles in Press	2026-02-28 06:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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