Publication Name	World Journal of Gastroenterology
Manuscript ID	118010
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Microbial metabolites and immune regulation in inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Invited Manuscript
All Author List	Zi-Ke Chen, Min Shi, Yuan-Bin Wu, Jia-Wei Zhao and Yu-Gang Wang
Funding Agency and Grant Number
Corresponding Author	Yu-Gang Wang, MD, PhD, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Shanghai 200336, China. wang_yugang@sina.com
Key Words	Gut-liver axis; Metabolic dysfunction-associated steatotic liver disease; Inflammatory bowel disease; Gut microbiota; Th17-regulatory T cell balance
Core Tip	This letter expands upon the seminal review by Sokal-Dembowska et al. It emphasizes the need to explore the functional consequences of microbial metabolite shifts and the complexity of Th17/regulatory T cell immunology in the gut-liver dialogue of inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease. Specifically, it highlights how specific metabolites and pathogenic Th17 subsets drive hepatic injury and discusses the translational relevance of novel interleukin-23 and sphingosine-1-phosphate receptor modulators.
Citation	Chen ZK, Shi M, Wu YB, Zhao JW, Wang YG. Microbial metabolites and immune regulation in inflammatory bowel disease and metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press

Received	2025-12-23 08:14
Peer-Review Started	2025-12-23 08:15
First Decision by Editorial Office Director	2026-01-20 09:28
Return for Revision	2026-01-20 09:28
Revised	2026-01-27 13:41
Publication Fee Transferred
Second Decision by Editor	2026-02-28 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-28 06:44
Articles in Press	2026-02-28 06:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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