Publication Name	World Journal of Gastroenterology
Manuscript ID	118036
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Sex-specific differences in the efficacy and prognosis of 5-aminosalicylic acid therapy for ulcerative colitis: A 20-year retrospective cohort study
Manuscript Source	Unsolicited Manuscript
All Author List	Zhao-Shi Liu, Hao Tang, Hui-Min Zhang, Xiao-Yin Bai, Hong Yang, Xiao-Feng Li and Jia-Ming Qian
Funding Agency and Grant Number	Funding Agency Grant Number Health Research and Special Projects Grant of China No. 201002020 CAMS Innovation Fund for Medical Sciences No. 2016-I2M-3-001
Corresponding Author	Jia-Ming Qian, Chief Physician, MD, Professor, Department of Gastroenterology, Peking Union Medical College Hospital, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. qianjm@pumch.cn
Key Words	Ulcerative colitis; Inflammatory bowel disease; 5-aminosalicylic acid; Sex-specific differences; Efficacy; Prognosis; Endoscopic mucosal healing; Colectomy; Surgery
Core Tip	Real-world data concerning sex-specific differences in the response to and long-term outcomes of 5-aminosalicylic acid (5-ASA) therapy for ulcerative colitis (UC) in large-scale UC cohorts are lacking. This retrospective study analyzed 354 patients receiving 5-ASA treatment after 1:1 propensity score matching. Male patients had an increased chance of frequent UC flare-ups, less frequent and delayed endoscopic mucosal healing, and a higher risk of surgery. These findings emphasize the need for sex-adapted therapeutic strategies to optimize 5-ASA utilization and improve individualized UC management.
Citation	Liu ZS, Tang H, Zhang HM, Bai XY, Yang H, Li XF, Qian JM. Sex-specific differences in the efficacy and prognosis of 5-aminosalicylic acid therapy for ulcerative colitis: A 20-year retrospective cohort study. World J Gastroenterol 2026; In press

Received	2025-12-26 02:07
Peer-Review Started	2025-12-26 02:07
First Decision by Editorial Office Director	2026-02-02 04:06
Return for Revision	2026-02-02 04:06
Revised	2026-02-13 10:42
Publication Fee Transferred	2026-02-15 03:49
Second Decision by Editor	2026-03-09 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 08:03
Articles in Press	2026-03-09 08:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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