Publication Name	World Journal of Clinical Cases
Manuscript ID	118053
Country	India

Category	Pediatrics
Manuscript Type	Randomized Controlled Trial
Article Title	Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars
Manuscript Source	Invited Manuscript
All Author List	Olando Kevin D’Souza
Funding Agency and Grant Number
Corresponding Author	Olando Kevin D’Souza, Consultant, Department of Pedodontics and Preventive Dentistry, Goa Dental College and Hospital, Near Goa Medical College, Bambolim 403202, Goa, India. olandokevindsouza@gmail.com
Key Words	Local anesthesia; Articaine; Lignocaine; Hypomineralized second primary molars; Efficacy
Core Tip	Achieving effective pulpal anesthesia in hypomineralized second primary molars is often challenging with conventional local anesthetics. This split-mouth clinical study demonstrates that 4% articaine provides superior intraoperative anesthetic efficacy compared with 2% lignocaine during root canal treatment of hypomineralized second primary molars, particularly during access cavity preparation and canal instrumentation. While both agents showed comparable discomfort during injection, articaine achieved more profound and consistent pulpal anesthesia. The findings underscore the clinical importance of selecting anesthetic agents with enhanced tissue penetration for hypomineralized teeth and provide evidence-based guidance for improving pain control and treatment outcomes in pediatric endodontic practice.
Citation	D’Souza OK. Comparative evaluation of anesthetic efficacy of articaine vs lignocaine during root canal therapy in hypomineralized second primary molars. World J Clin Cases 2026; In press

Received	2025-12-23 06:36
Peer-Review Started	2025-12-23 06:36
First Decision by Editorial Office Director	2026-01-28 08:40
Return for Revision	2026-01-28 08:40
Revised	2026-02-10 04:45
Publication Fee Transferred
Second Decision by Editor	2026-03-06 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 06:05
Articles in Press	2026-03-06 06:05
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2307-8960 (online)
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