Publication Name	World Journal of Gastroenterology
Manuscript ID	118140
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation
Manuscript Source	Unsolicited Manuscript
All Author List	Lin Yang, Dong-Xu Liao, Xiao-Yu Wang, Yong-Hong Fan, Zhu-Lin Luo and Yi Wen
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 32471419 National Key Clinical Specialty Project 41732113 Independent Innovation Project of General Hospital of Western Theater Command 2024-YGLC-B03
Corresponding Author	Yi Wen, MD, Department of General Surgery & Tissue Stress Injury and Functional Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Jinniu District, Chengdu 610083, Sichuan Province, China. 13980881194@163.com
Key Words	Severe acute pancreatitis; Peritoneal macrophages; Cell polarization; Curcumin; Nanoparticles
Core Tip	This study provides the first evidence that curcumin nanoparticles (Cur-NPs) alleviate the early inflammatory response in severe acute pancreatitis by activating nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway to regulate polarization of peritoneal macrophages. Cur-NPs significantly ameliorated pancreatic tissue damage and reduced serum levels of inflammatory factors. Cur-NPs exerted therapeutic effects by inducing a shift in macrophage polarization from the proinflammatory M1 to anti-inflammatory M2 phenotype. Activation of the HO-1 pathway via promoted Nrf2 nuclear translocation mediated the suppressive effect of Cur-NPs on the nuclear factor kappa-B signaling pathway and oxidative stress.
Citation	Yang L, Liao DX, Wang XY, Fan YH, Luo ZL, Wen Y. Curcumin nanoparticles mitigate early inflammation in severe acute pancreatitis by modulating peritoneal macrophage polarization via Nrf2/HO-1 pathway activation. World J Gastroenterol 2026; In press

Received	2025-12-25 03:37
Peer-Review Started	2025-12-25 03:37
First Decision by Editorial Office Director	2026-01-21 09:27
Return for Revision	2026-01-21 09:27
Revised	2026-02-03 10:15
Publication Fee Transferred	2026-02-04 08:08
Second Decision by Editor	2026-03-17 03:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 09:56
Articles in Press	2026-03-17 09:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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