Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118174
Country	India

Category	Pediatrics
Manuscript Type	Review
Article Title	Interface between inborn errors of immunity and rheumatological disorders in children: A pediatrician’s conundrum
Manuscript Source	Invited Manuscript
All Author List	Abarna Thangaraj, Ridhima Aggarwal, Soumyadeep Sarkar and Rakesh Kumar Pilania
Funding Agency and Grant Number	Funding Agency Grant Number na
Corresponding Author	Rakesh Kumar Pilania, Pediatric Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, APC 4A, 4127, Advanced pediatrics, Chandigarh 160012, India. kumarpilania007@gmail.com
Key Words	Inborn errors of immunity; Rheumatology; Monogenic disease; Immune dysregulation; Children
Core Tip	Rheumatological disorders in children may represent the initial manifestation of inborn errors of immunity (IEIs), a rapidly expanding group of monogenic immune dysregulation syndromes. Increasing overlap exists between IEIs and pediatric rheumatologic diseases, including arthritis, vasculitis, cytopenias, lupus, macrophage activation syndrome, and polyautoimmunity. Early age of onset, atypical or severe disease, recurrent infections, multi-organ involvement, and poor response to standard therapy are key red flags. Early recognition and genetic diagnosis enable precision-based targeted therapies, significantly improving outcomes.
Citation	Thangaraj A, Aggarwal R, Sarkar S, Pilania RK. Interface between inborn errors of immunity and rheumatological disorders in children: A pediatrician’s conundrum. World J Clin Pediatr 2026; In press

Received	2025-12-29 01:22
Peer-Review Started	2025-12-29 01:23
First Decision by Editorial Office Director	2026-01-23 08:17
Return for Revision	2026-01-23 08:17
Revised	2026-02-20 13:51
Publication Fee Transferred
Second Decision by Editor	2026-04-03 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 05:09
Articles in Press	2026-04-03 05:09
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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