Publication Name	World Journal of Clinical Oncology
Manuscript ID	118350
Country	Pakistan

Category	Oncology
Manuscript Type	Prospective Study
Article Title	Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study
Manuscript Source	Invited Manuscript
All Author List	Sabeen Nasir, Asif Ali, Ihsan Ullah, Shabnam Wazir, Irum Javaid, Summaya Z Jalal, Ishaq Khan and Muhammed Mubarak
Funding Agency and Grant Number
Corresponding Author	Muhammed Mubarak, Department of Histopathology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sindh, Pakistan. drmubaraksiut@yahoo.com
Key Words	Low-grade glioma; High-grade glioma; Cytoskeletal protein nestin; Survival analysis; Tumour grade
Core Tip	Gliomas show marked biological heterogeneity, necessitating accessible prognostic biomarkers, especially in resource-limited settings. This prospective study demonstrates that nestin overexpression is significantly associated with higher tumour grade and inferior overall survival in both low- and high-grade gliomas. High-grade tumours showed markedly increased nestin expression and substantially shorter survival compared to low-grade counterparts. Patients with high nestin expression experienced poorer outcomes, while the combined analysis revealed the worst prognosis in high-grade gliomas with high nestin levels. These findings highlight nestin as a practical supplementary prognostic marker that may aid risk stratification where advanced molecular testing is unavailable.
Citation	Nasir S, Ali A, Ullah I, Wazir S, Javaid I, Jalal SZ, Khan I, Mubarak M. Clinicopathological and prognostic relevance of nestin in low- and high-grade gliomas: An immunohistochemical study. World J Clin Oncol 2026; In press

Received	2025-12-30 06:07
Peer-Review Started	2025-12-30 06:07
First Decision by Editorial Office Director	2026-01-06 09:51
Return for Revision	2026-01-06 09:51
Revised	2026-01-10 07:49
Publication Fee Transferred
Second Decision by Editor	2026-03-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 08:31
Articles in Press	2026-03-09 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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