Publication Name	World Journal of Transplantation
Manuscript ID	118357
Country	India

Category	Ophthalmology
Manuscript Type	Observational Study
Article Title	Microbiological spectrum and probability of transmission of infection from ocular tissues of enucleated eyes harvested from septicemic donors
Manuscript Source	Invited Manuscript
All Author List	Aditi Dubey, Priyanka ., Deepak Soni, Deepti Chaurasia, Brindha Periasamy, Nikhila C Jain, Deepayan Sarkar, Mamta Singh, Srishti Khullar, Kavita Kumar, Pragyil Chaturvedi and Bhavana Sharma
Funding Agency and Grant Number
Corresponding Author	Bhavana Sharma, Head, Professor, Department of Ophthalmology, All India Institute of Medical Sciences Bhopal, Saket Nagar, Bhopal 462020, Madhya Pradesh, India. drbhavana_s@yahoo.co.in
Key Words	Corneal transplantation; Septicemia; Corneal blindness; Donor tissue contamination; Eye banking
Core Tip	Corneal transplantation remains an important sight restoring procedure, but has major demand-supply gap of donor corneas, worsened by exclusion of septicemic donors due to presumed infection risk. This bicentric cross-sectional study evaluated the microbiological spectrum of ocular tissues harvested from septicemic donors and their potential risk of infection transmission. Cultures from conjunctiva, cornea, sclera, aqueous, vitreous, and post-mortem blood were assessed and correlated. Microbial growth rates were comparable between groups, with organisms largely reflecting commensal flora. Only one corneal and scleral sample matched blood culture isolates. A strong association was found between longer death-to-retrieval time and contamination. Overall, septicemia did not significantly compromise tissue sterility, suggesting potential reconsideration of transplantation guidelines to reduce tissue wastage.
Citation	Dubey A, P, Soni D, Chaurasia D, Periasamy B, Jain NC, Sarkar D, Singh M, Khullar S, Kumar K, Chaturvedi P, Sharma B. Microbiological spectrum and probability of transmission of infection from ocular tissues of enucleated eyes harvested from septicemic donors. World J Transplant 2026; In press

Received	2025-12-31 00:41
Peer-Review Started	2025-12-31 00:41
First Decision by Editorial Office Director	2026-01-07 08:46
Return for Revision	2026-01-07 08:46
Revised	2026-01-19 12:14
Publication Fee Transferred
Second Decision by Editor	2026-03-20 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-20 07:20
Articles in Press	2026-03-20 07:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com