Publication Name	World Journal of Stem Cells
Manuscript ID	118401
Country	China

Category	Andrology
Manuscript Type	Minireviews
Article Title	Single-cell transcriptomics reveals a spermatogonial stem cell-centered spermatogenic microenvironment: Pathophysiological mechanisms and therapeutic targets in male infertility
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Kang Ying, Xin-Yu Xu, Jia-Wei Hu, Yun Cui and Da-Wei Jiang
Funding Agency and Grant Number	Funding Agency Grant Number Jiaxing Municipal Health Science and Technology Plan Key Project JWKD-25010 Special Scientific Research Project of the Affiliated Hospital of Zhejiang Chinese Medical University 2024FSYYZQ17
Corresponding Author	Da-Wei Jiang, PhD, Department of Andrology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University, No. 1501 Zhongshan East Road, Nanhu District, Jiaxing 314001, Zhejiang Province, China. yush1128@yeah.net
Key Words	Single-cell transcriptomics; Spermatogonial stem cell; Testicular microenvironment; Male infertility; NLRP3 inflammasome
Core Tip	This review integrates single-cell transcriptomics data from 2018 to 2025 to reconstruct the pathological landscape of male infertility, identifying the spermatogonial stem cell niche as a core therapeutic target. We elucidate a novel mechanistic axis linking “inflammaging” and NLRP3 inflammasome activation to spermatogonial stem cell depletion in non-obstructive azoospermia. Furthermore, we critically evaluate translational barriers, including geographic data bias and technical limitations, and propose a precision medicine framework integrating multiethnic cohorts to bridge the gap between single-cell atlases and clinical andrology.
Citation	Ying ZK, Xu XY, Hu JW, Cui Y, Jiang DW. Single-cell transcriptomics reveals a spermatogonial stem cell-centered spermatogenic microenvironment: Pathophysiological mechanisms and therapeutic targets in male infertility. World J Stem Cells 2026; In press

Received	2025-12-31 02:48
Peer-Review Started	2025-12-31 02:50
First Decision by Editorial Office Director	2026-01-16 03:43
Return for Revision	2026-01-16 03:43
Revised	2026-01-22 18:50
Publication Fee Transferred	2026-01-26 13:13
Second Decision by Editor	2026-03-02 02:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 09:51
Articles in Press	2026-03-09 09:51
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ISSN	1948-0210 (online)
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