Publication Name	World Journal of Virology
Manuscript ID	118445
Country	Greece

Category	Respiratory System
Manuscript Type	Systematic Reviews
Article Title	Human metapneumovirus infection in pregnancy: A systematic review of cohort studies and case reports
Manuscript Source	Invited Manuscript
All Author List	Aikaterini Tsantila, Kleanthi Gourounti, Christina Nanou, Dimitra Metallinou, Vasiliki E Georgakopoulou, Angeliki Bolou and Athina Diamanti
Funding Agency and Grant Number
Corresponding Author	Vasiliki E Georgakopoulou, Department of Pathophysiology, Laiko General Hospital, Medical School of National and Kapodistrian University of Athens, 17 Agiou Toma Street, Athens 11527, Greece. vaso_georgakopoulou@hotmail.com
Key Words	Obstetric outcomes; Viral infection; Pregnancy; Human metapneumovirus; Neonatal outcomes
Core Tip	Human metapneumovirus (hMPV) is an under-recognized cause of respiratory illness during pregnancy. This systematic review synthesizes all available evidence on laboratory-confirmed hMPV infection in pregnant women, integrating data from community-based cohorts and hospital-based case reports. Most antenatal hMPV infections are mild and self-limited; however, severe pneumonia and acute respiratory distress syndrome can occur, particularly in women with underlying comorbidities. Obstetric and neonatal outcomes are generally reassuring, although a possible association with fetal growth restriction warrants further investigation. These findings highlight the need for greater clinical awareness of hMPV in pregnancy and for prospective studies to better define maternal and perinatal risks.
Citation	Tsantila A, Gourounti K, Nanou C, Metallinou D, Georgakopoulou VE, Angeliki Bolou, Diamanti A. Human metapneumovirus infection in pregnancy: A systematic review of cohort studies and case reports. World J Virol 2026; In press

Received	2026-01-04 02:04
Peer-Review Started	2026-01-04 02:04
First Decision by Editorial Office Director	2026-02-13 07:37
Return for Revision	2026-02-13 07:37
Revised	2026-02-14 20:36
Publication Fee Transferred
Second Decision by Editor	2026-03-17 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 08:31
Articles in Press	2026-03-17 08:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3249 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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