Publication Name	World Journal of Psychiatry
Manuscript ID	118509
Country	China

Category	Obstetrics & Gynecology
Manuscript Type	Correspondence
Article Title	Letter to the Editor: Re-evaluating fixed thyroid thresholds in postpartum depression risk stratification
Manuscript Source	Invited Manuscript
All Author List	Huan Zhang, Sheng-Mei Lu, Miao-Miao Deng, Na Dong and Kang-Kang Ji
Funding Agency and Grant Number
Corresponding Author	Kang-Kang Ji, PhD, College of Biomedicine and Health, Huazhong Agricultural University, No. 1 Shizishan Street, Wuhan 430070, Hubei Province, China. kyrie@mail.ustc.edu.cn
Key Words	Postpartum depression; Adverse pregnancy outcomes; Risk stratification; Thyroid thresholds
Core Tip	Chen et al identified thyroid-stimulating hormone ≥ 3 mIU/L and thyroid peroxidase antibody ≥ 7 U/mL as independent predictors for adverse pregnancy outcomes (APOs) in postpartum depression (PPD). While this underscores the thyroid-PPD link, reliance on universal, fixed thresholds is problematic. Pregnancy induces profound, individualized thyroid physiological changes, making static cut-offs potentially misleading for risk stratification. Future research must prioritize trimester-specific reference ranges and longitudinal biomarker profiling to capture dynamic thyroid-autoimmune interactions and refine personalized prediction models for PPD and APOs.
Citation	Zhang H, Lu SM, Deng MM, Dong N, Ji KK. Letter to the Editor: Re-evaluating fixed thyroid thresholds in postpartum depression risk stratification. World J Psychiatry 2026; In press

Received	2026-01-04 06:45
Peer-Review Started	2026-01-04 06:46
First Decision by Editorial Office Director	2026-02-09 09:18
Return for Revision	2026-02-09 09:18
Revised	2026-02-12 06:23
Publication Fee Transferred
Second Decision by Editor	2026-03-31 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-31 10:11
Articles in Press	2026-03-31 10:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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