Publication Name	World Journal of Hepatology
Manuscript ID	118548
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Bile acid receptor signaling in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and emerging therapeutic strategies
Manuscript Source	Unsolicited Manuscript
All Author List	Sanjay Bandyopadhyay, Shambo Samrat Samajdar, Shatavisa Mukherjee and Shashank R Joshi
Funding Agency and Grant Number
Corresponding Author	Sanjay Bandyopadhyay, DM, FRCP, Head, Department of Gastroenterology, ILS Dumdum Hospital, 1 Mall Road, Kolkata 700080, West Bengal, India. drsanjaygastro@gmail.com
Key Words	Metabolic dysfunction-associated steatotic liver disease; Bile acid receptors; Farnesoid X receptor; Takeda G-protein-coupled receptor 5; Norursodeoxycholic acid
Core Tip	Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a global health challenge with limited pharmacological options. This review highlights the emerging role of bile acid receptors - particularly farnesoid X receptor (FXR) and Takeda G-protein-coupled receptor 5 - as therapeutic targets in MASLD. It synthesizes recent advances in receptor signaling, gut microbiota-bile acid interactions, and the development of FXR agonists, norursodeoxycholic acid, and dual FXR/Takeda G-protein-coupled receptor 5 agents. The review also outlines future directions in precision hepatology, proposing receptor-specific, microbiome-informed strategies for managing MASLD.
Citation	Bandyopadhyay S, Samajdar SS, Mukherjee S, Joshi SR. Bile acid receptor signaling in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and emerging therapeutic strategies. World J Hepatol 2026; In press

Received	2026-01-05 08:31
Peer-Review Started	2026-01-05 08:33
First Decision by Editorial Office Director	2026-01-28 09:10
Return for Revision	2026-01-28 09:10
Revised	2026-02-10 02:48
Publication Fee Transferred	2026-02-15 14:23
Second Decision by Editor	2026-04-03 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 08:10
Articles in Press	2026-04-03 08:10
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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