Publication Name	World Journal of Gastroenterology
Manuscript ID	118587
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Amy K Kim, Selena Y Lin, Hsin-Ni Liu, Surbhi Jain, Terence P Gade, Fwu-Shan Shieh, James Hamilton, Hie-Won Hann, Ting-Tsung Chang, Dmitry Goryunov, Zhili Wang and Ying-Hsiu Su
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health W81XWH-20-1-0605, 1K08CA237624-01A1 National Institutes of Health 5R44HG008700-03 National Institutes of Health 5R01CA202769-05, 1U01CA275648-01 National Institutes of Health 5R44CA165312-07, 1R43AI167169-01
Corresponding Author	Ying-Hsiu Su, /, Baruch S. Blumberg Institute, 3805 Old Easton Road, Doylestown, PA 18902, United States. ying-hsiu.su@bblumberg.org
Key Words	Cell-free DNA; Hepatocellular carcinoma; Urine; Hepatocellular carcinoma mutation; Liquid biopsy
Core Tip	Urinary cell-free DNA may serve as a simple, non-invasive tool for detecting liver cancer (hepatocellular carcinoma). In this study, we found that urine contains shorter, tumor-specific DNA fragments and unique genetic markers that help distinguish liver cancer patients from those with other chronic liver conditions. With similar accuracy to blood-based tests and the advantage of easier sample collection, urine cell-free DNA has the potential to improve liver cancer diagnosis and monitoring.
Citation	Kim AK, Lin SY, Liu HN, Jain S, Gade TP, Shieh FS, Hamilton J, Hann HW, Chang TT, Goryunov D, Wang Z, Su YH. Urinary cell-free DNA as a noninvasive liquid biopsy for hepatocellular carcinoma. World J Gastroenterol 2026; In press

Received	2026-01-13 06:56
Peer-Review Started	2026-01-13 06:57
First Decision by Editorial Office Director	2026-03-05 09:51
Return for Revision	2026-03-05 09:51
Revised	2026-03-10 14:56
Publication Fee Transferred
Second Decision by Editor	2026-05-15 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 08:02
Articles in Press	2026-05-15 08:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com