Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118614
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Fan Li, Song-Nan Du, Peng-Tao Bao and Yu-Geng Li
Funding Agency and Grant Number
Corresponding Author	Yu-Geng Li, -, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), No. 4 Renmin Road, Shibei District, Qingdao 266033, Shandong Province, China. qq252656554@163.com
Key Words	Gastric cancer; Immunochemotherapy; Prognostic prediction; Multidimensional nomogram; Efficacy
Core Tip	The immunochemotherapy regimen of programmed cell death-1 inhibitors combined with chemotherapy offers new therapeutic prospects for patients with human epidermal growth factor receptor-2-negative advanced gastric cancer. However, significant interindividual heterogeneity in treatment response poses challenges to precise clinical decision-making. Yao et al constructed a multidimensional nomogram prediction model by integrating clinical, molecular, and inflammatory-nutritional indices. Innovatively incorporating immune biomarkers, clinicopathological features, and host systemic status, this model was validated using the concordance index, area under the curve, and calibration curves. Despite limitations including a single-center retrospective design and a relatively small sample size, the nomogram provides a valuable tool for prognostic prediction in this patient population and establishes a paradigm for the construction of tumor prognostic models in the future.
Citation	Li MF, Du SN, Bao PT, Li YG. Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer. World J Gastrointest Oncol 2026; In press

Received	2026-01-07 06:36
Peer-Review Started	2026-01-07 06:37
First Decision by Editorial Office Director	2026-01-23 07:57
Return for Revision	2026-01-23 07:57
Revised	2026-01-31 15:18
Publication Fee Transferred
Second Decision by Editor	2026-03-06 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 06:44
Articles in Press	2026-03-06 06:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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