Publication Name	World Journal of Gastroenterology
Manuscript ID	118624
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Beyond inflammation control: Rethinking fatigue as a multidimensional target in Crohn’s disease management
Manuscript Source	Invited Manuscript
All Author List	Xue Gao, Ping Xiao, Jian-Qi Di, Yan Jiao and Qing Liu
Funding Agency and Grant Number
Corresponding Author	Yan Jiao, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. lagelangri1@126.com
Key Words	Crohn’s disease; Fatigue; Psychological distress; Gut-brain axis; Immune imbalance; Quality of life
Core Tip	Fatigue in Crohn’s disease persists in a substantial proportion of patients despite adequate control of intestinal inflammation and is increasingly recognized as a multidimensional clinical problem. Accumulating evidence suggests that psychological distress, sleep disturbance, and neuroimmune dysregulation play a central role in the pathogenesis and maintenance of fatigue, often outweighing traditional contributors such as anemia or biochemical disease activity. These editorial challenges the inflammation-centric paradigm and highlights fatigue as a distinct therapeutic target. Integrating mental health assessment, lifestyle factors, and emerging gut-brain axis mechanisms into routine care may substantially improve patient-reported outcomes and long-term quality of life in Crohn’s disease.
Citation	Gao X, Xiao P, Di JQ, Jiao Y, Liu Q. Beyond inflammation control: Rethinking fatigue as a multidimensional target in Crohn’s disease management. World J Gastroenterol 2026; In press

Received	2026-01-07 03:34
Peer-Review Started	2026-01-07 03:35
First Decision by Editorial Office Director	2026-01-23 10:03
Return for Revision	2026-01-23 10:03
Revised	2026-01-24 05:03
Publication Fee Transferred
Second Decision by Editor	2026-02-28 02:32
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-28 06:57
Articles in Press	2026-02-28 06:57
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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