Publication Name	World Journal of Biological Chemistry
Manuscript ID	118705
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation
Manuscript Source	Invited Manuscript
All Author List	Ao-Yun Zhang, Cong-Yi Xie, Xiao Song, Zi-Han Guo, Yu-Rou Shi, Shuai-Yan Wang, Guan-Hu Yang, Yun Liu and Tian-Cheng Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation No. 82305376 The Youth Talent Support Project of the China Acupuncture and Moxibustion Association No. 2024-2026ZGZJXH-QNRC005 The 2024 Jiangsu Province Youth Science and Technology Talent Support Project No. JSTJ-2024-380 Jiangsu Science and Technology Think Tank Program Project No. 2025-20-35
Corresponding Author	Tian-Cheng Xu, Academic Fellow, CEO, Chairman, Consultant, Full Professor, Head, MD, PhD, President, Professor, Visiting Professor, Key Laboratory of Acupuncture and Medicine Research of Ministry of Education, Nanjing University of Chinese Medicine, No. 138 Xianlin Avenue, Qixia District, Nanjing 210023, Jiangsu Province, China. xtc@njucm.edu.cn
Key Words	Triggering receptor expressed on myeloid cells 2; Obesity; Pancreatic macrophages; Pancreatic inflammation; Immunometabolism
Core Tip	Triggering receptor expressed on myeloid cells pancreatic macrophages represent a promising therapeutic target bridging obesity, islet inflammation, and metabolic disorders. The central theme of this review focuses on the phenotypic remodeling characteristics of macrophages in obesity, the regulatory mechanisms of triggering receptor expressed on myeloid cells 2, and its impacts on macrophage-β cell crosstalk, followed by a discussion on translational prospects and challenges.
Citation	Zhang AY, Xie CY, Song X, Guo ZH, Shi YR, Wang SY, Yang GH, Liu Y, Xu TC. Triggering receptor expressed on myeloid cells 2-driven pancreatic macrophage crosstalk: Key regulator of obesity pathophysiology and metabolic dysregulation. World J Biol Chem 2026; In press

Received	2026-01-09 03:43
Peer-Review Started	2026-01-09 03:44
First Decision by Editorial Office Director	2026-02-14 07:35
Return for Revision	2026-02-14 07:35
Revised	2026-02-25 12:25
Publication Fee Transferred
Second Decision by Editor	2026-05-12 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-12 05:38
Articles in Press	2026-05-12 05:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8454 (online)
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