Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118708
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Moderately to poorly differentiated adenocarcinoma invading a leiomyoma: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Qin-Jian Wang, Jia-Ni Gao, Ping-Ting Wu, Guang-Rong Lu and Xian-Zuo Xu
Funding Agency and Grant Number	Funding Agency Grant Number Wenzhou Science and Technology Bureau No. Y20240207
Corresponding Author	Xian-Zuo Xu, Department of Gastroenterology, The Third People’s Hospital of Cangnan County, No. 2288 Yucang Road, Cangnan Countye, Wenzhou 325000, Zhejiang Province, China. 13706653410@163.com
Key Words	Submucosal tumor; Gastric leiomyoma; Gastric adenocarcinoma; Overlying; Collision tumor; Immunohistochemistry; Endoscopic submucosal dissection
Core Tip	Gastric collision tumors featuring adenocarcinoma invading leiomyoma are extremely rare, posing diagnostic and therapeutic challenges. This case describes a 59-year-old male with recurrent abdominal bloating, diagnosed via a multimodal approach: Gastroscopy, endoscopic ultrasound, contrast-enhanced computed tomography, histopathology, and immunohistochemistry. Immunohistochemistry (smooth muscle actin, desmin positivity for leiomyoma; cytokeratin-pan positivity for adenocarcinoma) was pivotal for definitive diagnosis. Endoscopic submucosal dissection (ESD) achieved en bloc resection with uneventful recovery and no recurrence at 8-month follow-up. Notably, the benign leiomyoma may have constrained malignant invasion, facilitating ESD feasibility. This report underscores the necessity of comprehensive diagnostics and supports ESD as a minimally invasive option for localized lesions, warranting further research on the tumor-stroma interaction.
Citation	Wang QJ, Gao JN, Wu PT, Lu GR, Xu XZ. Moderately to poorly differentiated adenocarcinoma invading a leiomyoma: A case report. World J Gastrointest Oncol 2026; In press

Received	2026-01-12 06:18
Peer-Review Started	2026-01-12 06:22
First Decision by Editorial Office Director	2026-01-23 10:06
Return for Revision	2026-01-23 13:06
Revised	2026-02-03 15:12
Publication Fee Transferred	2026-02-07 09:22
Second Decision by Editor	2026-03-16 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 08:44
Articles in Press	2026-03-17 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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