Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118730
Country	Peru

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review
Manuscript Source	Invited Manuscript
All Author List	Jenyfer M Fuentes-Mendoza, Marcio J Concepción-Zavaleta, Luisa Graciela Dongo-Dueñas, Jose Mariano J Jara-Pianto, Jhosmar Angel Sierra-Martel, Claudio Aldahir Medina-Angulo, Horus Michael Virú-Flores, Jeny J Mendoza-Godoy, Francisca E Zavaleta-Gutiérrez and José Paz-Ibarra
Funding Agency and Grant Number
Corresponding Author	Marcio J Concepción-Zavaleta, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe
Key Words	Adolescent obesity; Pediatric obesity; Anti-obesity medications; Weight reduction; Adherence; Quality of life
Core Tip	This minireview demonstrates that current evidence confirms that lifestyle interventions are insufficient for severe cases, proposing pharmacotherapy as a clinical necessity, where glucagon-like peptide 1 receptor agonists, especially semaglutide, are positioned as the current standard of care; while critically evaluating the horizon of dual agonists and other combinations. The article identifies new structural barriers such as high costs, global shortages, and strict insurance requirements. It highlights the urgency of conducting new direct comparisons emphasizing the need to integrate data from ongoing Food and Drug Administration-mandated post-marketing surveillance and prospective registries to monitor outcomes in pubertal maturation, bone health, and neurobiological impact.
Citation	Fuentes-Mendoza JM, Concepción-Zavaleta MJ, Dongo-Dueñas LG, Jara-Pianto JMJ, Sierra-Martel JA, Medina-Angulo CA, Virú-Flores HM, Mendoza-Godoy JJ, Zavaleta-Gutiérrez FE, Paz-Ibarra J. Current and forthcoming pharmacotherapies for adolescent obesity: Evidence-based review. World J Clin Pediatr 2026; In press

Received	2026-01-12 01:36
Peer-Review Started	2026-01-12 01:36
First Decision by Editorial Office Director	2026-01-30 09:02
Return for Revision	2026-01-30 09:02
Revised	2026-02-02 18:56
Publication Fee Transferred
Second Decision by Editor	2026-03-12 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 08:00
Articles in Press	2026-03-12 08:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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