Publication Name	World Journal of Gastroenterology
Manuscript ID	118745
Country	China

Category	Microbiology
Manuscript Type	Minireviews
Article Title	Circadian clock at the interface of mucosal immunity, gut microbiota and epithelial barrier in inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Ke-Xin Yu and Zhan-Jun Lu
Funding Agency and Grant Number
Corresponding Author	Zhan-Jun Lu, Associate Chief Physician, MD, Department of Gastroenterology, Jintan Affiliated Hospital of Jiangsu University, No. 500 Avenue Jintan, Jintan 213200, Jiangsu Province, China. zhanjun.lu@shgh.cn
Key Words	Inflammatory bowel disease; Circadian rhythm; Clock genes; Gut microbiota; Epithelial barrier; Chronotherapy; Intestinal homeostasis
Core Tip	Disrupted circadian clock gene networks link mucosal immune imbalance, gut microbiota dysbiosis, and epithelial barrier failure in inflammatory bowel disease. Chronotherapy, particularly behavioral interventions, such as stabilizing sleep-wake schedules and meal timing, is a plausible avenue. However, evidence supporting medication timing in the treatment of IBD remains limited and heterogeneous. Thus, rigorous prospective trials are needed before clinical recommendations can be made.
Citation	Yu KX, Lu ZJ. Circadian clock at the interface of mucosal immunity, gut microbiota and epithelial barrier in inflammatory bowel disease. World J Gastroenterol 2026; In press

Received	2026-01-12 07:10
Peer-Review Started	2026-01-12 07:10
First Decision by Editorial Office Director	2026-01-21 09:33
Return for Revision	2026-01-21 09:33
Revised	2026-01-31 20:10
Publication Fee Transferred	2026-02-05 10:08
Second Decision by Editor	2026-03-17 03:05
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 10:18
Articles in Press	2026-03-17 10:18
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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