Publication Name	World Journal of Psychiatry
Manuscript ID	118781
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Fibroblast growth factor receptor 1: Bridge to understanding mental disorders
Manuscript Source	Invited Manuscript
All Author List	Fei Fan, Bo Wang, Zi-Lin Chen, Wei-Feng Li and Fei Han
Funding Agency and Grant Number	Funding Agency Grant Number The Fundamental Research Funds for the Central Public Welfare Research Institutes No. ZZ17-XRZ-043
Corresponding Author	Fei Han, Professor, Department of Paediatrics, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No. 5 Beixiange, Xicheng District, Beijing 100053, China. hf4383@126.com
Key Words	Fibroblast growth factor receptor 1; Mental disorders; Neurodevelopment; Synaptic plasticity; Schizophrenia; Depression
Core Tip	This review establishes fibroblast growth factor receptor 1 (FGFR1) as a central signaling integrator in mental disorders, moving beyond its traditional developmental roles. We highlight novel mechanisms including dynamic heteroreceptor complex formation with neurotransmitter receptors and essential neuron-glia communication, through which FGFR1 regulates synaptic and circuit plasticity. These insights directly link FGFR1 pathway dysregulation to the pathophysiology of depression and schizophrenia, positioning it as a compelling and druggable target for next-generation therapeutics.
Citation	Fan F, Wang B, Chen ZL, Li WF, Han F. Fibroblast growth factor receptor 1: Bridge to understanding mental disorders. World J Psychiatry 2026; In press

Received	2026-01-12 03:12
Peer-Review Started	2026-01-12 03:13
First Decision by Editorial Office Director	2026-03-02 08:37
Return for Revision	2026-03-02 08:37
Revised	2026-03-13 15:36
Publication Fee Transferred
Second Decision by Editor	2026-05-11 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-11 10:07
Articles in Press	2026-05-11 10:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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