Publication Name	World Journal of Gastroenterology
Manuscript ID	118814
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Specificity protein 1/ZIP8/zinc axis reduced macrophage extracellular traps to alleviate severe acute pancreatitis in mice
Manuscript Source	Unsolicited Manuscript
All Author List	Yi-Miao Cheng, Qiong Liu, Zu-Xing Wei, Xiao-Yan Qi, Jun He and Xu-Yang Hou
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Hunan Province No. 2023JJ40821 Natural Science Foundation of Changsha City No. kq2208308 Hunan Provincial Health Commission Health Research Project No. W20243029
Corresponding Author	Xu-Yang Hou, Department of Cardiovascular Surgery, The Second Xiangya Hospital, Central South University, No. 139 Renmin Road, Changsha 410011, Hunan Province, China. houxuyang@csu.edu.cn
Key Words	Macrophage extracellular traps; Severe acute pancreatitis; Specificity protein 1; ZIP8; Zinc
Core Tip	This study reveals that severe acute pancreatitis triggers macrophage extracellular trap (MET) formation in M1 macrophages through peptidylarginine deiminase 4 and reactive oxygen species pathways, linked to zinc deficiency and ZIP expression downregulation. Zinc supplementation and ZIP8 overexpression mitigate MET formation and organ injury. Additionally, specificity protein 1’s role in regulating ZIP8 expression is highlighted, with its downregulation exacerbating zinc deficiency and MET formation, offering novel insights into therapeutic strategies.
Citation	Cheng YM, Liu Q, Wei ZX, Qi XY, He J, Hou XY. Specificity protein 1/ZIP8/zinc axis reduced macrophage extracellular traps to alleviate severe acute pancreatitis in mice. World J Gastroenterol 2026; In press

Received	2026-01-12 06:28
Peer-Review Started	2026-01-12 06:28
First Decision by Editorial Office Director	2026-02-13 07:56
Return for Revision	2026-02-13 07:56
Revised	2026-03-09 04:28
Publication Fee Transferred	2026-03-10 04:06
Second Decision by Editor	2026-04-03 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 07:38
Articles in Press	2026-04-03 07:38
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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