Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	118862
Country	Syria

Category	Pediatrics
Manuscript Type	Randomized Controlled Trial
Article Title	Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn
Manuscript Source	Invited Manuscript
All Author List	Sania El-Hindi
Funding Agency and Grant Number
Corresponding Author	Sania El-Hindi, Consultant, Doctorate Student, pediatric cardiology, Children's Hospital - Damascus University, Damascus, Syria, mazzeh, Damascus 011, Dimashq, Syria. saniahindi@yahoo.com
Key Words	Persistent pulmonary; Hypertension of the newborn; Vardenafil; Sildenafil; Pulmonary vascular resistance; Phosphodiesterase inhibitors
Core Tip	This is the first randomized controlled trial to evaluate the efficacy of vardenafil in the management of patients with persistent pulmonary hypertension of the newborn (PPHN). The study demonstrated that improvements in pulmonary hypertension, pulmonary vascular resistance, pulmonary artery flow velocity, and respiratory distress were faster in the vardenafil group than in sildenafil group without adverse events. These findings if confirmed in larger clinical trials may position vardenafil as a preferred first-line therapy for PPHN particularly in resource limited settings.
Citation	El-Hindi S. Vardenafil efficacy for the treatment of persistent pulmonary hypertension of the newborn. World J Clin Pediatr 2026; In press

Received	2026-01-13 06:08
Peer-Review Started	2026-01-13 06:08
First Decision by Editorial Office Director	2026-02-12 08:23
Return for Revision	2026-02-12 08:23
Revised	2026-02-13 22:01
Publication Fee Transferred
Second Decision by Editor	2026-04-03 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 06:49
Articles in Press	2026-04-03 06:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2219-2808 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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