Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118867
Country	China

Category	Medicine, General & Internal
Manuscript Type	Retrospective Study
Article Title	Endoscopic ultrasonography lesion thickness predicts deep invasion in gastric cancer: Development and temporal validation of a preoperative model
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Yu Cao, Yu-Fan Chen, Yun-Xiu Liao, Qing Yang, Shi-Yong Lin, Yin Li, Jun Weng, Xin-Xin Huang, Xiao-Yan Gao, Guo-Bao Wang, Hong-Bo Shan and Jian-Jun Li
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Tibet Autonomous Region for Group Medical Assistance Project XZ2019ZR-ZY60(Z) Guangzhou Clinical Specialty Technology Construction Project 2026P-TS016
Corresponding Author	Hong-Bo Shan, Chief Physician, MD, PhD, Senior Research Fellow, Department of Endoscopy, Sun Yat-sen University Cancer Center, No. 651 Dongfengdong Street, Yuexiu District, Guangzhou 510060, Guangdong Province, China. shanhb@sysucc.org.cn
Key Words	Gastric cancer; Endoscopic ultrasonography; Lesion thickness; Tumour invasion depth; Preoperative prediction; Risk model
Core Tip	Preoperative identification of deep gastric wall invasion remains challenging. Endoscopic ultrasonography provides both a categorical T stage and a measurable lesion thickness. We developed and internally validated a logistic model that treats lesion thickness as a continuous predictor, together with routinely available clinical variables, to estimate individualised risk of pathological ≥ pT3 disease. The model showed good discrimination and decision-curve utility, and outperformed uT-based benchmarks. Temporal testing in a later same-institution cohort preserved discrimination but showed calibration drift, supporting future recalibration, external validation, and context-specific threshold selection.
Citation	Cao MY, Chen YF, Liao YX, Yang Q, Lin SY, Li Y, Weng J, Huang XX, Gao XY, Wang GB, Shan HB, Li JJ. Endoscopic ultrasonography lesion thickness predicts deep invasion in gastric cancer: Development and temporal validation of a preoperative model. World J Gastrointest Oncol 2026; In press

Received	2026-01-14 03:17
Peer-Review Started	2026-01-14 03:18
First Decision by Editorial Office Director	2026-02-13 07:57
Return for Revision	2026-02-14 14:59
Revised	2026-02-26 13:18
Publication Fee Transferred	2026-03-01 02:44
Second Decision by Editor	2026-03-31 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-31 08:27
Articles in Press	2026-03-31 08:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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