Publication Name	World Journal of Hepatology
Manuscript ID	118902
Country	Russia

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Metabolic links between metabolic dysfunction-associated steatotic liver disease and primary biliary cholangitis
Manuscript Source	Invited Manuscript
All Author List	Stanislav Kotlyarov
Funding Agency and Grant Number
Corresponding Author	Stanislav Kotlyarov, PhD, Department of Nurse, Ryazan State Medical University, Vysokovoltnaya 9, Ryazan 390005, Russia. skmr1@yandex.ru
Key Words	Primary biliary cholangitis; Metabolic dysfunction-associated steatotic liver disease; Adipokines; Adiponectin; Leptin; Immunometabolism; Gut microbiota; Oxidative stress; Mitochondrial dysfunction; Leptin/adiponectin ratio
Core Tip	The increase in metabolic disorders has led to the comorbidity of primary biliary cholangitis (PBC) and metabolic dysfunction-associated steatotic liver disease (MASLD) becoming increasingly common. Beyond simple comorbidity, these conditions cause complex immunometabolic cross-talk involving common pathways of immune dysregulation, lipid metabolism alterations, adipokine imbalance, and gut microbiota dysfunction. Recent data suggest that in patients with PBC, concomitant MASLD disrupts the characteristic hyperadiponectinemia associated with cholestasis, leading to a specific adipokine profile with an elevated leptin/adiponectin ratio. This Editorial summarizes current understanding of the pathogenetic relationships between PBC and MASLD, analyzes new clinical data on their bidirectional effects, and identifies critical gaps in knowledge. Understanding these interactions is important for developing personalized therapeutic approaches and improving treatment outcomes for patients with this increasingly recognized dual pathology.
Citation	Kotlyarov S. Metabolic links between metabolic dysfunction-associated steatotic liver disease and primary biliary cholangitis. World J Hepatol 2026; In press

Received	2026-01-14 00:29
Peer-Review Started	2026-01-14 00:30
First Decision by Editorial Office Director	2026-01-19 08:49
Return for Revision	2026-01-19 08:49
Revised	2026-01-26 09:08
Publication Fee Transferred
Second Decision by Editor	2026-03-06 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 08:32
Articles in Press	2026-03-06 08:32
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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