Publication Name	World Journal of Gastroenterology
Manuscript ID	118923
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Chang, Rong Sun, Wei Juan, Zheng Xu, Hao-Yu Xu, Ke Zen and Ji Xuan
Funding Agency and Grant Number
Corresponding Author	Ji Xuan, Department of Gastroenterology, Jinling Clinical Medical College, Nanjing University of Chinese Medicine, Zhongshan East Road 305, Nanjing 210002, Jiangsu Province, China., Nanjing 210002, Jiangsu Province, China. xuanji@nju.edu.cn
Key Words	Chronic radiation proctitis; Endoscopic views; Endoscopic scoring; Tubulin; Rat model
Core Tip	Chronic radiation proctitis can be induced by a single dose of 20-35 Gy irradiation, which simplifies the modeling procedure while recapitulating two major human pathological features: Telangiectasia and progressive fibrosis. The formation of chronic injury is associated with the destruction of microtubule protein, the low expression of tubulin at 2 weeks after irradiation can serve as an early indicator for the transition of rectal toward chronic radiation injury. After radiation without intervention, around the eighth week, chronic manifestations such as capillary dilation would appear. The observation period for the therapeutic effect should be extended to at least 8 weeks.
Citation	Chang Y, Sun R, Juan W, Xu Z, Xu HY, Zen K, Xuan J. Establishment of a standardized rat model of chronic radiation proctitis and preliminary evaluation of its association with tubulin. World J Gastroenterol 2026; In press

Received	2026-01-22 00:49
Peer-Review Started	2026-01-22 00:49
First Decision by Editorial Office Director	2026-02-02 09:19
Return for Revision	2026-02-02 09:19
Revised	2026-02-26 21:37
Publication Fee Transferred	2026-03-04 14:44
Second Decision by Editor	2026-03-17 03:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 09:24
Articles in Press	2026-03-17 09:24
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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