Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	118948
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Ye Sun, Na Fu, Dan-Dan Zhao, Zheng-Lu Wang, Lei Cao, Jia-Li Qiu, Yi Li, Wei Gao, Jin-Liang Duan, Lin Li and Yue-Min Nan
Funding Agency and Grant Number	Funding Agency Grant Number Key Research and Development Program of Hebei Province-Biomedical Innovation Project 23377705D Introduction of Foreign Intelligence Program in Hebei Province in 2024
Corresponding Author	Yue-Min Nan, Chief, MD, PhD, Department of Traditional and Western Medical Hepatology, Hebei Medical University Third Hospital, No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang 050051, Hebei Province, China. nanyuemin@hebmu.edu.cn
Key Words	Hepatocellular carcinoma; Exosomal microRNAs; Diagnostic model; MicroRNA-200b-3p; Phosphoserine aminotransferase 1; Liquid biopsy
Core Tip	This study developed and validated a novel three-exosomal-miRNA (miR-200b-3p, miR-215-5p, miR-452-5p) and age-based diagnostic model for hepatocellular carcinoma (HCC) using a rigorous multi-cohort design. The model demonstrated high accuracy with an area under the curve of 0.863, offering a robust non-invasive tool for early detection. Furthermore, we experimentally identified phosphoserine aminotransferase 1 as a direct functional target of miR-200b-3p, establishing its tumor-suppressive role in HCC. Our work provides both a clinically promising liquid biopsy biomarker panel and a key mechanistic insight, advancing the field of precision diagnosis for HCC.
Citation	Sun XY, Fu N, Zhao DD, Wang ZL, Cao L, Qiu JL, Li Y, Gao W, Duan JL, Li L, Nan YM. Integrated diagnostic model based on serum exosomal microRNAs and functional mechanism of miR-200b-3p in hepatocellular carcinoma. World J Gastrointest Oncol 2026; In press

Received	2026-01-15 06:06
Peer-Review Started	2026-01-15 06:06
First Decision by Editorial Office Director	2026-03-06 09:23
Return for Revision	2026-03-07 01:23
Revised	2026-03-20 12:55
Publication Fee Transferred	2026-03-27 01:30
Second Decision by Editor	2026-05-14 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-14 08:49
Articles in Press	2026-05-14 08:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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