Publication Name	World Journal of Clinical Oncology
Manuscript ID	118954
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	New breakthroughs and future trends in renal cell carcinoma therapy from the European Society for Medical Oncology 2025
Manuscript Source	Unsolicited Manuscript
All Author List	Zhen-Yu Liu, Yu Zhou, Fu-Han Zhao, Lin Wang, Tie-Jun Pan and Lei Gao
Funding Agency and Grant Number	Funding Agency Grant Number the Natural Science Foundation of Hubei Province No. 2023AFB498 Natural Science Foundation Exploration Plan (Morning Light Plan) of Wuhan City No. 2024040801020363 Postdoctoral Scientific Research Foundation, General Hospital of Central Theater Command No. 20230102KY39
Corresponding Author	Lei Gao, Professor, Department of Urology, General Hospital of Central Theater Command of Chinese People's Liberation Army, Wuluo Road, Zhongnan Street, Wuhan, Hubei, Wuhan 430070, Hubei Province, China. 511376424@qq.com
Key Words	Renal cell carcinoma; Precision medicine; European Society for Medical Oncology 2025; Immunotherapy; Biomarkers
Core Tip	This timely review synthesizes pivotal advances in renal cell carcinoma management presented at the European Society for Medical Oncology 2025 Congress. It highlights the shift towards precision medicine, evidenced by risk-stratified adjuvant immune checkpoint inhibitor therapy, promising short-course neoadjuvant immune checkpoint inhibitor strategies, and the evolution towards triple-combination regimens in advanced disease. A parallel focus is the critical development of predictive biomarkers - from molecular classifiers to artificial intelligence-based pathology tools - to guide individualized treatment selection and optimize outcomes across the disease spectrum, marking a decisive move beyond a one-size-fits-all therapeutic approach.
Citation	Liu ZY, Zhou Y, Zhao FH, Wang L, Pan TJ, Gao L. New breakthroughs and future trends in renal cell carcinoma therapy from the European Society for Medical Oncology 2025. World J Clin Oncol 2026; In press

Received	2026-01-16 07:04
Peer-Review Started	2026-01-16 07:04
First Decision by Editorial Office Director	2026-01-22 08:32
Return for Revision	2026-01-22 08:32
Revised	2026-01-29 11:24
Publication Fee Transferred	2026-02-02 02:44
Second Decision by Editor	2026-03-06 02:34
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-06 07:08
Articles in Press	2026-03-06 07:08
Edit the Manuscript by Language Editor	2026-03-07 10:47
Typeset the Manuscript

ISSN	2218-4333 (online)
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