Publication Name	World Journal of Transplantation
Manuscript ID	118962
Country	Italy

Category	Surgery
Manuscript Type	Letter to the Editor
Article Title	Induction therapy as a long-term commitment: Lessons from comparative outcomes of alemtuzumab and basiliximab
Manuscript Source	Invited Manuscript
All Author List	Luca Galassi, Erica Altamura, Lina Azzahrani, Federica Facchinetti and Matteo Lino Ravini
Funding Agency and Grant Number
Corresponding Author	Luca Galassi, Lecturer, MD, Researcher, Postgraduate School of Vascular and Endovascular Surgery, University of Milan, Festa del Perdono Street, Milan 20122, Lombardy, Italy. luca.galassi@unimi.it
Key Words	Kidney transplantation; Induction therapy; Alemtuzumab; Basiliximab; Graft survival; Immunological debt; Precision medicine; Patient safety
Core Tip	The choice of induction therapy in kidney transplantation has commonly been centered around short-term rejection outcomes, which do not reliably predict the long-term safety and graft outcomes. Evidence reveals that, despite similar rejection rates, alemtuzumab is associated with increased risks of infection and malignancy and reduced graft survival among standard-risk recipients. These data support a risk-stratified approach to induction therapy, advocating non-lymphocyte-depleting agents for standard-risk patients and reserving lymphocyte-depleting induction for selected high-risk recipients.
Citation	Galassi L, Altamura E, Azzahrani L, Facchinetti F, Ravini ML. Induction therapy as a long-term commitment: Lessons from comparative outcomes of alemtuzumab and basiliximab. World J Transplant 2026; In press

Received	2026-01-15 03:37
Peer-Review Started	2026-01-15 03:38
First Decision by Editorial Office Director	2026-02-02 09:07
Return for Revision	2026-02-02 09:07
Revised	2026-02-09 19:48
Publication Fee Transferred
Second Decision by Editor	2026-03-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 10:03
Articles in Press	2026-03-09 10:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3230 (online)
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