Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	119130
Country	China

Category	Oncology
Manuscript Type	Case Control Study
Article Title	Premna microphylla Turcz. reshapes nutritional metabolism via the Simulator of the Human Intestinal Microbial Ecosystem model
Manuscript Source	Unsolicited Manuscript
All Author List	Hui-Di Zhu, Chang Xu, Sheng-Hong Guan, Yu-Ming Lou, Kan-Kai Zhu, Run-Feng Lin, Hai-Long Jin, Shuo Chai, Xiao-Yong Zhang, Xiao-Sun Liu and Jing-Kui Tian
Funding Agency and Grant Number	Funding Agency Grant Number Joint Traditional Chinese Medicine Science & Technology Projects of National Demonstration Zones for Comprehensive Traditional Chinese Medicine Reform ZY-KJS-ZJ-2025-052 Joint Traditional Chinese Medicine Science & Technology Projects of National Demonstration Zones for Comprehensive Traditional Chinese Medicine Reform GZY-KJS-ZJ-2025-036 Key Research & Development Plan of Zhejiang Province 2025C02171
Corresponding Author	Xiao-Sun Liu, Professor, Department of Gastrointestinal Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, No. 366, Wutong Road, Hangzhou 310000, Zhejiang Province, China. xiaosunliu@zju.edu.cn
Key Words	Gastric cancer; Chemotherapy combined with immunotherapy; Nutritional bioactivity; Simulator of the Human Intestinal Microbial Ecosystem; Premna microphylla Turcz
Core Tip	This study established an intestinal microbial ecosystem (Simulator of the Human Intestinal Microbial Ecosystem) model to uncover the differential absorption and metabolism profiles of Premna microphylla Turcz. (PMT) across various intestinal segments. We demonstrated that chemotherapy-induced gut microbiota dysbiosis leads to a shift in the primary absorption site of active ingredients toward the colon. These findings not only provide a scientific basis for developing novel strategies to improve cancer patient prognosis but also lay a solid theoretical foundation for utilizing PMT as a low-toxicity therapeutic agent.
Citation	Zhu HD, Xu C, Guan SH, Lou YM, Zhu KK, Lin RF, Jin HL, Chai S, Zhang XY, Liu XS, Tian JK. Premna microphylla Turcz. reshapes nutritional metabolism via the Simulator of the Human Intestinal Microbial Ecosystem model. World J Gastrointest Oncol 2026; In press

Received	2026-01-20 07:01
Peer-Review Started	2026-01-20 07:02
First Decision by Editorial Office Director	2026-01-28 08:00
Return for Revision	2026-01-28 08:00
Revised	2026-02-10 11:48
Publication Fee Transferred	2026-02-15 06:26
Second Decision by Editor	2026-03-12 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 07:20
Articles in Press	2026-03-12 07:20
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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