Publication Name	World Journal of Clinical Oncology
Manuscript ID	119163
Country	Saudi Arabia

Category	Oncology
Manuscript Type	Minireviews
Article Title	Immunomodulatory and antitumor effects of shilajit and glycine: Natural metabolic modulators targeting breast and liver cancer
Manuscript Source	Invited Manuscript
All Author List	Tasneem A Basbrain, Nidal M Zabermawi, Jehan S Alrahimi and Kawther A Zaher
Funding Agency and Grant Number
Corresponding Author	Kawther A Zaher, Professor, Department of Immunology Unit, King Fahd Medical Research Center, and Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Gamaa Road, Jeddah 21589, Saudi Arabia. kzaher@kau.edu.sa
Key Words	Shilajit; Glycine; Immunometabolism; One-carbon metabolism; Tumor microenvironment; Breast cancer; Hepatocellular carcinoma; Natural products
Core Tip	Shilajit and glycine are low-cost natural agents with convergent immunometabolic activity relevant to breast cancer and hepatocellular carcinoma. This minireview summarizes how shilajit fractions and glycine-dependent redox and one-carbon pathways may modulate oxidative stress, inflammatory signaling, and immune-cell polarization within the tumor microenvironment. We highlight practical translational priorities, including extract standardization, pharmacokinetic constraints, biomarker-guided patient stratification, and rational combinations with established anticancer therapies.
Citation	Basbrain TA, Zabermawi NM, Alrahimi JS, Zaher KA. Immunomodulatory and antitumor effects of shilajit and glycine: Natural metabolic modulators targeting breast and liver cancer. World J Clin Oncol 2026; In press

Received	2026-01-20 00:58
Peer-Review Started	2026-01-20 00:58
First Decision by Editorial Office Director	2026-01-28 08:42
Return for Revision	2026-01-28 08:42
Revised	2026-02-06 00:35
Publication Fee Transferred
Second Decision by Editor	2026-03-13 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 04:11
Articles in Press	2026-03-13 04:11
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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