Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	119164
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Bilirubin normalization: A crucial outcome to assess in biliary drainage
Manuscript Source	Invited Manuscript
All Author List	Alberto Martino, Francesco Paolo Zito, Annalisa de Leone, Savio Saviano, Raffaele Bennato and Giovanni Lombardi
Funding Agency and Grant Number
Corresponding Author	Alberto Martino, Department of Gastroenterology and Digestive Endoscopy, AORN “Antonio Cardarelli”, Via Antonio Cardarelli 9, Napoli 80131, Italy. alberto.martino@aocardarelli.it
Key Words	Endoscopic retrograde cholangiopancreatography; Endoscopic ultrasound-guided biliary drainage; Biliary obstruction; Distal biliary obstruction; Distal malignant biliary obstruction; Bilirubin normalization
Core Tip	The bilirubin normalization is a key outcome in biliary drainage, especially in the malignant setting. However, despite its profound effect on clinical and oncological outcomes, the bilirubin normalization rate is generally underreported. Its systematic and standardized assessment should be strongly encouraged in future trials.
Citation	Martino A, Zito FP, de Leone A, Saviano S, Bennato R, Lombardi G. Bilirubin normalization: A crucial outcome to assess in biliary drainage. World J Gastrointest Endosc 2026; In press

Received	2026-01-20 01:30
Peer-Review Started	2026-01-20 01:31
First Decision by Editorial Office Director	2026-01-29 08:46
Return for Revision	2026-01-29 08:46
Revised	2026-02-02 13:47
Publication Fee Transferred
Second Decision by Editor	2026-03-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-09 09:58
Articles in Press	2026-03-09 09:58
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com