Publication Name	World Journal of Diabetes
Manuscript ID	119178
Country	United Kingdom

Category	Endocrinology & Metabolism
Manuscript Type	Opinion Review
Article Title	Helicobacter pylori and diabetic complications: Stronger evidence for the interlink
Manuscript Source	Invited Manuscript
All Author List	Sanja Medenica, Cornelius J Fernandez and Joseph M Pappachan
Funding Agency and Grant Number
Corresponding Author	Joseph M Pappachan, FRCP, MD, MRCP, Professor, Senior Researcher, Faculty of Science, Manchester Metropolitan University, All Saints Campus, Grosvenor Square, Manchester M15 6BH, Greater Manchester, United Kingdom. drpappachan@yahoo.co.in
Key Words	Autoimmune disorders; Helicobacter pylori; Metabolic dysregulation; Type 1 diabetes mellitus; Type 2 diabetes mellitus
Core Tip	Helicobacter pylori (H. pylori) infection is increasingly recognized as a systemic disease with important metabolic consequences. Growing evidence supports a bidirectional relationship between H. pylori infection and DM, particularly T2DM, in which chronic inflammation, insulin resistance, and immune dysregulation play central roles. Patients with DM and concomitant H. pylori infection appear to have a higher risk of gastrointestinal, hepatic, and renal complications. Recent experimental data further strengthen this association by demonstrating aggravated organ damage in diabetic models with H. pylori infection. Recognition of this interlink has important implications for screening, monitoring, and therapeutic strategies in patients with diabetes.
Citation	Medenica S, Fernandez CJ, Pappachan JM. Helicobacter pylori and diabetic complications: Stronger evidence for the interlink. World J Diabetes 2026; In press

Received	2026-01-21 00:24
Peer-Review Started	2026-01-29 09:14
First Decision by Editorial Office Director	2026-03-05 08:51
Return for Revision	2026-03-05 08:51
Revised	2026-03-29 17:29
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 06:26
Articles in Press	2026-05-06 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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