Publication Name	World Journal of Gastroenterology
Manuscript ID	119220
Country	China

Category	Surgery
Manuscript Type	Case Report
Article Title	Successful conversion therapy for advanced hepatocellular carcinoma with biliary tumor thrombus and bilateral lobe involvement: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Yu Zhang, Lu-Yang Zhang, Bo Meng, Yun-Jian Wang, Nan-Mu Yang, Qiong Li and Min Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Henan Province Science and Technology Research Project SBGJ202103035
Corresponding Author	Min Zhang, MD, PhD, Vice Director, Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University, No.127, Dongming Road, 450008, Zhengzhou, China, Zhengzhou 450008, Henan Province, China. zhangyuu2022@gs.zzu.edu.cn
Key Words	Hepatocellular carcinoma; Hepatocellular carcinoma-derived biliary tumor thrombus; Conversion therapy; Immunotherapy; Targeted therapy; Case report
Core Tip	For advanced bilateral multilobular hepatocellular carcinoma (HCC) with HCC-derived biliary tumor thrombus, conversion therapy using camrelizumab (immunotherapy) combined with apatinib mesylate (targeted therapy) and hepatic radiofrequency ablation successfully reduced tumor burden and eliminated the biliary tumor thrombus, enabling radical surgical resection. This approach resulted in short-term disease-free survival (6 months after surgery) with preserved normal liver function.
Citation	Zhang Y, Zhang LY, Meng B, Wang YJ, Yang NM, Li Q, Zhang M. Successful conversion therapy for advanced hepatocellular carcinoma with biliary tumor thrombus and bilateral lobe involvement: A case report. World J Gastroenterol 2026; In press

Received	2026-01-22 06:16
Peer-Review Started	2026-01-22 06:17
First Decision by Editorial Office Director	2026-02-04 10:06
Return for Revision	2026-02-04 10:06
Revised	2026-02-12 17:27
Publication Fee Transferred	2026-02-13 09:18
Second Decision by Editor	2026-03-12 02:36
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-12 08:44
Articles in Press	2026-03-12 08:44
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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