Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	119272
Country	China

Category	Oncology
Manuscript Type	Retrospective Cohort Study
Article Title	Efficacy and safety of adjuvant targeted immunotherapy for hepatocellular carcinoma with high recurrence risks after hepatectomy
Manuscript Source	Unsolicited Manuscript
All Author List	Qi-Sen Li, An-Yin Hu, Shao-Jie Chen, Gong-Jin Yu, Yi Fan, Yi-Gang Chen, She Tian, Ci-Jun Peng and Min Han
Funding Agency and Grant Number	Funding Agency Grant Number Guizhou Provincial Science and Technology Plan Project Qian-KH-[2024]-Youth-009
Corresponding Author	Ci-Jun Peng, PhD, Professor, Department of Hepatobiliary Surgery, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Guiyang 550001, Guizhou Province, China. doctorpengcijun@163.com
Key Words	Hepatocellular carcinoma; Hepatectomy; Recurrence; Adjuvant therapy; Tyrosine kinase inhibitors; Immune-checkpoint inhibitors; Cohort study
Core Tip	This retrospective cohort study demonstrates that adjuvant targeted and/or immunotherapy can significantly improve recurrence-free survival in hepatocellular carcinoma patients at high risk of recurrence after hepatectomy, compared to surgery alone. The therapy was identified as an independent protective factor against recurrence. While a clear overall survival benefit was not observed in this analysis, the treatment regimen showed a manageable safety profile, with most adverse events being reversible. These findings support the potential role of this adjuvant strategy in improving outcomes for this patient population.
Citation	Li QS, Hu AY, Chen SJ, Yu GJ, Fan Y, Chen YG, Tian S, Peng CJ, Han M. Efficacy and safety of adjuvant targeted immunotherapy for hepatocellular carcinoma with high recurrence risks after hepatectomy. World J Gastrointest Surg 2026; In press

Received	2026-01-23 05:59
Peer-Review Started	2026-01-23 06:01
First Decision by Editorial Office Director	2026-02-03 07:43
Return for Revision	2026-02-03 07:43
Revised	2026-02-11 23:33
Publication Fee Transferred	2026-02-13 05:01
Second Decision by Editor	2026-03-17 03:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-17 07:41
Articles in Press	2026-03-17 07:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9366 (online)
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