Publication Name	World Journal of Gastroenterology
Manuscript ID	119315
Country	China

Category	Oncology
Manuscript Type	Opinion Review
Article Title	RHEB-CSF1R signaling, autophagy, and metastatic plasticity in pancreatic cancer: Current advances, controversies, and translational opportunities
Manuscript Source	Invited Manuscript
All Author List	Jun-Xia Hu, Ye Zhang, Yue-Mei Chen and Lei Cao
Funding Agency and Grant Number
Corresponding Author	Lei Cao, Chief Physician, PhD, Professor, Department of Oncology, Jiangsu Province (Suqian) Hospital, No. 120 Suzhi Road, Sucheng District, Suqian 223800, Jiangsu Province, China. brawnym80@163.com
Key Words	Pancreatic cancer; Ras homolog enriched in brain; Colony stimulating factor 1 receptor; Autophagy; Phosphatidylinositol 3-kinase/protein kinase B/mammalian pathway; Epithelial-mesenchymal transition; Metastasis; Tumor microenvironment
Core Tip	A recent study comprehensively summarized that a tumor-cell ras homolog enriched in brain-colony stimulating factor 1 receptor complex promotes pancreatic cancer metastasis by increasing phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin phosphorylation, suppressing autophagy, and inducing epithelial-mesenchymal transition. Building on this work, the present article discusses how ras homolog enriched in brain-centered signaling may connect tumor-cell metabolic adaptation, macrophage-associated biology, autophagy regulation, and metastatic plasticity in pancreatic ductal adenocarcinoma. We emphasize current advances, major controversies, and translational opportunities, with particular focus on tumor-cell colony stimulating factor 1 receptor, autophagic flux, and biomarker-guided therapeutic development.
Citation	Hu JX, Zhang Y, Chen YM, Cao L. RHEB-CSF1R signaling, autophagy, and metastatic plasticity in pancreatic cancer: Current advances, controversies, and translational opportunities. World J Gastroenterol 2026; In press

Received	2026-01-26 01:20
Peer-Review Started	2026-01-26 01:20
First Decision by Editorial Office Director	2026-02-27 09:06
Return for Revision	2026-02-27 09:06
Revised	2026-03-09 14:30
Publication Fee Transferred
Second Decision by Editor	2026-05-06 03:20
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 07:33
Articles in Press	2026-05-06 07:33
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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