Publication Name	World Journal of Gastroenterology
Manuscript ID	119322
Country	United States

Category	Immunology
Manuscript Type	Opinion Review
Article Title	Adjacent nontumor mucosa: The overlooked frontier in colorectal cancer prognostication
Manuscript Source	Invited Manuscript
All Author List	Xiao-Jing Zhao and Xin-Yun Qiu
Funding Agency and Grant Number
Corresponding Author	Xin-Yun Qiu, Adjunct Associate Professor, MD, PhD, Visiting Professor, Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, United States. qiuxinyun2819@126.com
Key Words	Colorectal cancer; Adjacent nontumor mucosa; Macrophage polarization; Liver metastases; Prognostic biomarkers
Core Tip	Most immune profiling in colorectal cancer focuses on the tumor core, overlooking adjacent nontumor mucosa (NM). Ye et al show that NM macrophage subsets provide stage-specific prognostic signals after liver metastasectomy: Higher CD80-positive (M1-like) macrophages predict longer survival in stage I-III, while higher CD163-positive (M2-like) macrophages predict longer survival in stage IV. Tumor center metrics were not predictive. Incorporating NM immune profiling (CD80, CD163), alongside T-cell measures, could refine risk stratification and guide stage-tailored immune modulation.
Citation	Zhao XJ, Qiu XY. Adjacent nontumor mucosa: The overlooked frontier in colorectal cancer prognostication. World J Gastroenterol 2026; In press

Received	2026-01-26 01:18
Peer-Review Started	2026-01-26 01:20
First Decision by Editorial Office Director	2026-02-13 08:13
Return for Revision	2026-02-13 08:13
Revised	2026-03-01 07:39
Publication Fee Transferred
Second Decision by Editor	2026-03-13 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 06:15
Articles in Press	2026-03-13 06:15
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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