Publication Name	World Journal of Gastroenterology
Manuscript ID	119387
Country	Brazil

Category	Surgery
Manuscript Type	Meta-Analysis
Article Title	Impact of surgical vs medical management on histologic outcomes in Barrett’s esophagus: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Bruna B M Isbert, Dirceu F Valentini Jr, Vinicius J Campos, Luciano P Marcelino, Lorenzo O Dias and Richard R Gurski
Funding Agency and Grant Number
Corresponding Author	Richard R Gurski, Associate Professor, Chief, Chief Physician, Director, MD, PhD, Service of Digestive Surgery, Hospital de Clínicas de Porto Alegre (HCPA), No. 2350 Ramiro Barcelos Street, Porto Alegre 90035-903, Rio Grande do Sul, Brazil. rgurski@hcpa.edu.br
Key Words	Gastroesophageal reflux disease; Esophagus; Barrett’s esophagus; Adenocarcinoma; Fundoplication; Antireflux surgery; Nissen; Proton pump inhibitor
Core Tip	Barrett’s esophagus is a premalignant condition for which the optimal strategy to prevent disease progression remains uncertain. This systematic review and meta-analysis directly compared surgical fundoplication with proton pump inhibitor therapy. Fundoplication was associated with higher rates of histologic regression and a reduced risk of progression to high-grade dysplasia or esophageal adenocarcinoma. By focusing exclusively on these two treatment strategies, this study provides clinically meaningful comparative evidence to inform therapeutic decision-making and long-term management in this high-risk population.
Citation	Isbert BBM, Valentini Jr DF, Campos VJ, Marcelino LP, Dias LO, Gurski RR. Impact of surgical vs medical management on histologic outcomes in Barrett’s esophagus: A meta-analysis. World J Gastroenterol 2026; In press

Received	2026-01-26 02:41
Peer-Review Started	2026-01-26 02:41
First Decision by Editorial Office Director	2026-02-09 09:52
Return for Revision	2026-02-09 09:52
Revised	2026-02-22 00:46
Publication Fee Transferred	2026-03-19 23:15
Second Decision by Editor	2026-05-15 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-15 04:16
Articles in Press	2026-05-15 04:16
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com