Publication Name	World Journal of Cardiology
Manuscript ID	119394
Country	Egypt

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Opinion Review
Article Title	When the liver hardens the heart: Valvular calcification as an emerging cardiohepatic phenotype in cirrhosis
Manuscript Source	Invited Manuscript
All Author List	Yasser Fouad and Amr Abdel Zaher Shehata
Funding Agency and Grant Number
Corresponding Author	Yasser Fouad, Department of Gastroenterology and Endemic Medicine, Faculty of Medicine Minia University, Minia university, Minia 19111, Egypt. yasserfouad10@yahoo.com
Key Words	Cirrhosis; Cardiohepatic interaction; Valvular calcification; Metabolic dusfunction; Fatty liver; Risk stratification
Core Tip	One new but little-known aspect of cardiohepatic disease is valve calcification. According to the study by Vuckovic et al, cirrhosis of any aetiology strongly predicts mitral annular calcification, even in the presence of fewer conventional cardiovascular risk factors, whereas fatty liver-related cirrhosis is independently linked to aortic valve calcification. These results imply that a unique pro-calcific cardiovascular phenotype caused by hepatic and metabolic dysfunction is promoted by cirrhosis. Regular evaluation of cirrhosis and transplants should include echocardiographic assessment of valvular calcification to enhance cardiovascular risk stratification and facilitate early, multidisciplinary intervention.
Citation	Fouad Y, Shehata AAZ. When the liver hardens the heart: Valvular calcification as an emerging cardiohepatic phenotype in cirrhosis. World J Cardiol 2026; In press

Received	2026-01-26 00:40
Peer-Review Started	2026-01-26 00:42
First Decision by Editorial Office Director	2026-02-28 06:50
Return for Revision	2026-02-28 06:50
Revised	2026-03-01 15:54
Publication Fee Transferred
Second Decision by Editor	2026-04-03 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-04-03 06:27
Articles in Press	2026-04-03 06:27
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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