Publication Name	World Journal of Gastroenterology
Manuscript ID	119490
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Shao-Pu Hu, Yan-Ru Cai, Yang Liu, Yu-Xi Guo, Xue-Mei Jia, Jian-Ming Jiang and Qian Yang
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research Project of Hebei Provincial Administration of Traditional Chinese Medicine No. 2025213 Hebei Natural Science Foundation No. H2024423041 Hebei Natural Science Foundation No. H2023423001 Hebei Natural Science Foundation No. H2024423025 Merit-based Funding Project for Hebei Postdoctoral Researchers’ Scientific Research No. B2024005036
Corresponding Author	Qian Yang, MD, PhD, Professor, Department of Gastrointestinal Disease, The First Affiliated Hospital, Hebei University of Chinese Medicine, No. 389 Zhongshan East Road, Changan District, Shijiazhuang 050011, Hebei Province, China. yangqian6909@163.com
Key Words	Hua-Zhuo-Jie-Du formula; Colitis-associated colorectal cancer; Network pharmacology; Transcriptomics; Phosphatidylinositol 3-kinase/protein kinase B signaling pathway
Core Tip	Hua-Zhuo-Jie-Du formula (HZJDF) has been clinically proven to be effective at preventing colitis-associated colorectal cancer (CAC), but the mechanism for this requires further investigation. This study utilized ultra-high performance liquid chromatography-high-resolution mass spectrometry analysis, network pharmacology, and transcriptomics in an integrated approach to predict the material basis and potential mechanism of action of HZJDF in treating CAC. Furthermore, the prediction results were verified through animal and cell experiments. The results indicated that HZJDF effectively alleviated the tumorigenesis of CAC via inhibiting the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.
Citation	Hu SP, Cai YR, Liu Y, Guo YX, Jia XM, Jiang JM, Yang Q. Hua-Zhuo-Jie-Du formula alleviates colitis-associated colorectal cancer via regulating phosphatidylinositol 3-kinase/protein kinase B signaling pathway. World J Gastroenterol 2026; In press

Received	2026-01-29 03:01
Peer-Review Started	2026-01-29 03:01
First Decision by Editorial Office Director	2026-02-06 10:48
Return for Revision	2026-02-06 10:48
Revised	2026-02-12 11:06
Publication Fee Transferred	2026-02-13 00:45
Second Decision by Editor	2026-03-13 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-13 07:02
Articles in Press	2026-03-13 07:02
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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