Publication Name	World Journal of Cardiology
Manuscript ID	119509
Country	United States

Category	Respiratory System
Manuscript Type	Meta-Analysis
Article Title	Cardiovascular outcomes of sodium-glucose co-transporter-2 inhibitors in heart failure and coexisting chronic obstructive pulmonary disease: A meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Zaraq Ahmad Khan, Rohab Sohail, Ridda Khattak, Vyom Patel, Marcos Alberto Jr, Prakhar Anand, Andrei Feldiorean, Mark Georgy, Lindsey Marie Valdiviez, David Poldneff, Zoraiz Khan, Ibraheem Murtaza and Shawn Curry
Funding Agency and Grant Number
Corresponding Author	Zaraq Ahmad Khan, Department of Internal Medicine, Indiana University School of Medicine Southwest, 520 S 7th Street, Vincennes, IN 47591, United States. zaraqakhan@gmail.com
Key Words	Chronic obstructive pulmonary disease; Heart failure; Sodium-glucose co-transporter-2 inhibitors; Sodium-glucose co-transporter-2; Cardioprotective; Dapagliflozin; Empagliflozin
Core Tip	This meta-analysis evaluates the safety and efficacy of sodium-glucose co-transporter-2 inhibitors (SGLT-2I) in patients with congestive heart failure (HF) and coexisting chronic obstructive pulmonary disease, a population underrepresented in major HF trials. Across four randomized controlled trials, SGLT-2I significantly reduced HF hospitalizations and time-to-first hospitalization without increasing adverse events, while no mortality benefit was observed. These findings support the safe use of SGLT-2I to reduce hospitalization burden in this high-risk comorbid population.
Citation	Khan ZA, Sohail R, Khattak R, Patel V, Alberto Jr M, Anand P, Feldiorean A, Georgy M, Valdiviez LM, Poldneff D, Khan Z, Murtaza I, Curry S. Cardiovascular outcomes of sodium-glucose co-transporter-2 inhibitors in heart failure and coexisting chronic obstructive pulmonary disease: A meta-analysis. World J Cardiol 2026; In press

Received	2026-01-30 01:42
Peer-Review Started	2026-01-30 01:42
First Decision by Editorial Office Director	2026-02-06 10:14
Return for Revision	2026-02-06 10:14
Revised	2026-02-19 22:39
Publication Fee Transferred	2026-03-01 21:26
Second Decision by Editor	2026-05-06 03:18
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-05-06 08:48
Articles in Press	2026-05-06 08:48
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
Open Access	This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com